Award details

Characterisation and modelling of the Bacillus subtilis transcriptome during environmental stress

Reference	PRS12179
Principal Investigator / Supervisor	Professor Colin Harwood
Co-Investigators / Co-Supervisors	Professor Alan Ward
Institution	Newcastle University
Department	School of Cell and Molecular Biosciences
Funding type	Research
Value (£)	164,812
Status	Completed
Type	Research Grant
Start date	01/01/2000
End date	01/01/2003
Duration	36 months

Abstract

B. subtilis will be used as a model to study global transcriptional stress responses in Gram- positive bacteria since its stress responses have been studied intensively at the translational level and its genome has been sequenced. Whole genome ORFmer macroarrays will be used to measure changes in the transcriptome in response to applied environmental stresses. Software procedures will be devised to reveal gene families on the basis of their classification into temporal, stress induction and functional activities. A database will be established for data visualisation and interrogation. Changes in the transcriptome of defined mutants will be used to validate the cluster analyses and to characterise sigma B controlled general response proteins.

Summary

unavailable

Committee	Closed Committee - Plant & Microbial Sciences (PMS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	Prokaryotic Responses to Environmental Stress (PRS) [1999]
Funding Scheme	X – not Funded via a specific Funding Scheme

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