Award details

The role of the 3 CheW proteins of Rhodobacter in the formation of chemosensory clusters

Reference	PRS12171
Principal Investigator / Supervisor	Professor Judith Armitage
Co-Investigators / Co-Supervisors	Professor Susan Lea
Institution	University of Oxford
Department	Biochemistry
Funding type	Research
Value (£)	169,227
Status	Completed
Type	Research Grant
Start date	01/12/1999
End date	01/01/2003
Duration	37 months

Abstract

Chemosensory signal transduction probably involves the formation of dynamic clusters of receptors. In Rhodobacter sphaeroides, different receptors are expressed under different conditions and may be located at the poles of the cell or clustered in the cytoplasm. It is likely that the structural protein CheW is involved in the formation of clusters, R. sphaeroides has 3 CheW homologues. We will (i) identify which CheW proteins are involved in transmembrane receptor clustering and which in cytoplasmic clusters; (ii) which MCP proteins interact with which CheW proteins and whether the CheW proteins can complement; (iii) the domains involved in targeting the proteins to the specific receptors; (iv) the domains involved in interaction with the 3 CheA proteins and how these may be involved in signal transduction; (v) crystallise the proteins for structural comparison.

Summary

unavailable

Committee	Closed Committee - Plant & Microbial Sciences (PMS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	Prokaryotic Responses to Environmental Stress (PRS) [1999]
Funding Scheme	X – not Funded via a specific Funding Scheme

I accept the terms and conditions of use (opens in new window)

export PDF file

back to list new search