BBSRC Portfolio Analyser
Award details
Molecular interactions in the pathway regulating stress-specific transcription factor SigB of Bacillus subtilis
Reference
PRS12158
Principal Investigator / Supervisor
Dr M Yudkin
Co-Investigators /
Co-Supervisors
Institution
University of Oxford
Department
Biochemistry
Funding type
Research
Value (£)
193,864
Status
Completed
Type
Research Grant
Start date
01/01/2000
End date
30/06/2003
Duration
42 months
Abstract
SigB is regulated by a pathway consisting of several proteins arranged in two modules. The downstream module activates SigB when cells are starved. The upstream module transduced environmental signals to the downstream module. Communication between the various proteins is partly non-covalent interactions, and partly two pairs of protein kinases and phosphates. We shall study a) the dissociation constants of the non-covalent interactions; b) the intracellular concentration of each protein; c) kinetic properties of the kinases and phosphatases; d) the ratio of phosphorylated to non-phosphorylated substrates; e) phosphorylation and dephosphorylation of the protein thought to sense environmental signals and its homologues.
Summary
unavailable
Committee
Closed Committee - Plant & Microbial Sciences (PMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
Prokaryotic Responses to Environmental Stress (PRS) [1999]
Funding Scheme
X – not Funded via a specific Funding Scheme
I accept the
terms and conditions of use
(opens in new window)
export PDF file
back to list
new search