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The role of oxidative stress in the life of Staphylococcus aureus
Reference
PRS12152
Principal Investigator / Supervisor
Professor Simon J. Foster
Co-Investigators /
Co-Supervisors
Institution
University of Sheffield
Department
Molecular Biology and Biotechnology
Funding type
Research
Value (£)
171,124
Status
Completed
Type
Research Grant
Start date
01/12/1999
End date
01/12/2002
Duration
36 months
Abstract
Resistance to oxidative stress is crucial for the life of aerobic organisms. We have found that is particularly so for the human pathogen Staphylococcus aureus, during all phases of growth in vitro and pathogenesis. We have identified the major catalase of an important virulence determinant and starvation-survival component. The proposed project will characterise the role of specific oxidative stress resistance components during life in vitro and as part of the process of host-pathogen interaction. The regulatory mechanisms which control oxidative stress resistance in response to environmental stimuli will also be examined. The project will take an integrated approach to further our knowledge of how such a successful pathogen is able to adapt, in the face of adversity, to allow its continued survival in a hostile environment.
Summary
unavailable
Committee
Closed Committee - Plant & Microbial Sciences (PMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
Prokaryotic Responses to Environmental Stress (PRS) [1999]
Funding Scheme
X – not Funded via a specific Funding Scheme
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