Award details

Construction of a YAC contig for the chicken MHC-bearing microchromosome

Reference	PAG04440
Principal Investigator / Supervisor	Dr N Bumstead
Co-Investigators / Co-Supervisors	Dr Ayo Toye
Institution	The Pirbright Institute
Department	Div of Molecular Biology
Funding type	Research
Value (£)	128,250
Status	Completed
Type	Research Grant
Start date	01/10/1995
End date	01/10/1998
Duration	36 months

Abstract

This study will develop the first yeast artificial chromosome (YAC) contig of a chicken chromosome. It is only by the derivation of such contigs that genes can be isolated by positional mapping and this work will develop the necessary technology for chickens (methods applied in mice and humans cannot be applied in chickens due to the infrequency of repetitive sequences). Work will focus on the Mhc-bearing microchromosome, which is small, estimated to be less than 30 Mb in size. This microchromosome is of great interest to immunologists because of the similarities and striking differences between chicken and mammalian Mhc regions and because of the role of this region in the immune response. The contig will also provide the first opportunity to compare the structure of a whole chicken chromosome with mammalian chromosomes, and in future with the larger chicken chromosomes.

Summary

unavailable

Committee	Closed Committee - Genes & Developmental Biology (GDB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	Plant & Animal Genome Analysis (PAG) [1993-1995]
Funding Scheme	X – not Funded via a specific Funding Scheme

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