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Identification and characterisation of the plasmin (ogen) receptors of Streptococcus uberis and Streptococcus dysgalactiae
Reference
PAC02696
Principal Investigator / Supervisor
Professor James Leigh
Co-Investigators /
Co-Supervisors
Institution
The Pirbright Institute
Department
Div of Immunology Compton
Funding type
Research
Value (£)
155,462
Status
Completed
Type
Research Grant
Start date
21/04/1995
End date
21/04/1998
Duration
36 months
Abstract
1. To identify and isolate the molecules responsible for binding plasmin(ogen). 2. Characterise these with respect to their biochemical nature and biological function. 3. Clone the genes encoding the receptors. 4. Use the cloned genes to generate site directed mutants which lack receptor activity. 5. Compare the ability of such mutants to grow in biological fluids and resist phagocytosis by bovine neutrophils.
Summary
unavailable
Committee
Closed Committee - Animal Sciences (AS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
Pharmaceuticals/Chemicals - ROPA (PAC) [1994]
Funding Scheme
X – not Funded via a specific Funding Scheme
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