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In vitro studies of type II polyketide synthases components - control of polyketide chain assembly and cyclisation
Reference
PAC02678
Principal Investigator / Supervisor
Professor Thomas Simpson
Co-Investigators /
Co-Supervisors
Institution
University of Bristol
Department
Chemistry
Funding type
Research
Value (£)
168,362
Status
Completed
Type
Research Grant
Start date
01/01/1995
End date
01/05/1998
Duration
40 months
Abstract
1. Expression of ORFs 1-5 of Type II PKS gene clusters (9 months). 2. Isolation and purification of overexpressed gene products (9 months). 3. Biochemical characterisation and turnover studies with simple substrates and di, tri, and tetraketide intermediates (18 months).
Summary
unavailable
Committee
Closed Committee - Biomolecular Sciences (BMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
Pharmaceuticals/Chemicals - ROPA (PAC) [1994]
Funding Scheme
X – not Funded via a specific Funding Scheme
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