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Post-genomic analysis of Erwinia carotovora virulence regulon responses in vitro and in planta environments
Reference
P20288
Principal Investigator / Supervisor
Professor George Salmond
Co-Investigators /
Co-Supervisors
Institution
University of Cambridge
Department
Biochemistry
Funding type
Research
Value (£)
194,643
Status
Completed
Type
Research Grant
Start date
12/01/2004
End date
11/01/2007
Duration
36 months
Abstract
Erwinia carotovora subsp. atroseptica (Eca) causes potato blackleg and soft rot. The completed Eca genome sequence reveals many new potential pathogenicity genes and a virulence role for some suggests subtle roles in infection initiation. An Eca genomic microarray is under construction, also containing greater than 1000 potato genes involved in defence responses. This will be used with improved pathogenicity tests, and engineered mutants, to investigate if new pathogenicity genes are controlled by known global regulators, in vitro and in planta; to seek novel components and targets of the QS and Hrp regulons; and to identify host defence pathways modulated by pathogen effectors trafficked through the Type III pathway, or under QS control.
Summary
unavailable
Committee
Closed Committee - Plant & Microbial Sciences (PMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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