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DiGE proteomics of the Erwinia carotovora Type II secretome and functional analysis of its components in virulence
Reference
P20076
Principal Investigator / Supervisor
Professor George Salmond
Co-Investigators /
Co-Supervisors
Professor Kathryn Lilley
Institution
University of Cambridge
Department
Biochemistry
Funding type
Research
Value (£)
214,957
Status
Completed
Type
Research Grant
Start date
01/04/2004
End date
30/09/2007
Duration
42 months
Abstract
We will use cutting edge quantitative proteomic techniques and bacterial genetics to define the proteins (including known pathogenesis determinants) targeted through the key virulence factor conduit of the plant pathogen, Erwinia carotovora subsp. atroseptica (Eca). Novel factors defined in the Type II secretome and involved in phytopathogenesis will be assayed by functional genomic/proteomic approaches. The Type II secretome components will be identified; dependence on Sec, Tat and Dsb will be assigned and physiological and environmental modulation assayed. Type II secretome components routed via unconventional/novel mechanisms will be further investigated. The roles of secretome components in virulence will be assessed.
Summary
unavailable
Committee
Closed Committee - Plant & Microbial Sciences (PMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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