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Global iron regulation in E. coli

Reference	P20025
Principal Investigator / Supervisor	Professor Simon C Andrews
Co-Investigators / Co-Supervisors	Dr Andrea Robinson
Institution	University of Reading
Department	Animal and Microbial Sciences
Funding type	Research
Value (£)	359,586
Status	Completed
Type	Research Grant
Start date	01/03/2004
End date	28/02/2007
Duration	36 months

Abstract

Our DNA-array analysis of Fe/Fur (Fe uptake regulator) dependent gene expression in E. coli has identified 14 potential novel Fe-transporter genes, and a major new category of Fe-controlled genes encoding Fe-proteins involved in respiration which suggests a new iron-homeostatic mechanism. We now aim to perform a more extensive analysis of Fe/Fur regulation in E. coli and to identify the functions (or rationale for Fe regulation) of some of the more interesting Fe/Fur regulated genes identified by us so far: several predicted Fe transporters including one related to Ftr1p of yeast; a Cu exporter (the Cus system); a ribonucleotide reductase (NrdFEIH); and the Ni transporter. We also intend to characterise the Fe/Fur-controlled extracellular reductase activity of E. coli and investigate the role of the Suf system in scavenging cellular Fe during Fe restricted growth.

Summary

unavailable

Committee	Closed Committee - Plant & Microbial Sciences (PMS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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