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Functional characterisations of Rex a novel redox sensing regulator in Streptomyces coelicolor
Reference
P19928
Principal Investigator / Supervisor
Dr Mark Paget
Co-Investigators /
Co-Supervisors
Institution
University of Sussex
Department
Biology and Environmental Science
Funding type
Research
Value (£)
197,989
Status
Completed
Type
Research Grant
Start date
01/05/2004
End date
30/04/2007
Duration
36 months
Abstract
Oxygen supply is often a crucial factor in determining product yield during Streptomyces fermentations, yet little is known about how these bacteria sense and respond to changes in oxygen tension. We have discovered a novel regulator called Rex that modulates the expression of several respiratory genes. Rather than sense oxygen directly Rex senses changes in the cellular redox balance that result from a decrease in the rate of respiration. We propose to: (i) isolate and characterise a rex mutant; (ii) define regions of Rex involved in DNA binding and redox sensing; (iii) identify the Rex regulon; and (iv) use biochemical approaches to gain insights into how changes in cellular redox balance affects the DNA binding activity of Rex.
Summary
unavailable
Committee
Closed Committee - Plant & Microbial Sciences (PMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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