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The integration and regulation of galactose metabolism in plants
Reference
P19451
Principal Investigator / Supervisor
Professor Keith Roberts
Co-Investigators /
Co-Supervisors
Dr Georg Seifert
Institution
John Innes Centre
Department
Cell and Develop Biology
Funding type
Research
Value (£)
223,280
Status
Completed
Type
Research Grant
Start date
01/08/2003
End date
31/07/2006
Duration
36 months
Abstract
We have recently cloned and characterised the RHD1 gene from Arabidopsis (2) that encodes one member of a family of five UDP-Galactose 4-epimerases (UGE), a key enzyme in galactose metabolism. Loss of function rhd1 mutations confer a clear root morphological phenotype and show reduced galactose in only two particular cell wall polysaccharides, yet all five UGE enzymes are cytosolic and all appear to be ubiquitously expressed. By looking at the detailed cellular and sub-cellular expression pattern of the enzyme family, and by characterizing the interacting proteins partners of UGE4/RHD1, we will use this new genetic model to understand how each isoform manages to direct galactose into different end products and how this important aspect of sugar metabolism in plants is regulated.
Summary
unavailable
Committee
Closed Committee - Plant & Microbial Sciences (PMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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