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Understanding the mechanism by which extracellular signals activate hemicellulase gene expression
Reference
P19432
Principal Investigator / Supervisor
Professor Harry Gilbert
Co-Investigators /
Co-Supervisors
Professor Nigel Robinson
Institution
Newcastle University
Department
Agriculture Food and Rural Development
Funding type
Research
Value (£)
214,696
Status
Completed
Type
Research Grant
Start date
01/10/2003
End date
30/09/2006
Duration
36 months
Abstract
The general model for the control of prokaryotic plant cell wall hydrolases is that constitutive enzymes release small saccharides that enter the bacterial cytoplasm and bind to regulatory proteins modulating their activity. Preliminary data suggest that signalling cascades culminating in hemicellulase expression in the bacterium Cellvibrio cellulosa are activated by molecular inducers to membrane bound sensor proteins. The aim of this project is to: 1) test the hypothesis that two-component systems are key elements in bacterial hemicellulase expression; and 2) to identify the molecular inducers binding that activate the signalling cascades that culminate in hemicellulase expression. Resolution of this latter question will establish whether each signalling cascade is activated by one or range of different molecular cues and will determine to what extent there is cross-talk between the different regulatory circuits.
Summary
unavailable
Committee
Closed Committee - Plant & Microbial Sciences (PMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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