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Functional analysis of metacaspase genes in Arabidopsis

Reference	P19341
Principal Investigator / Supervisor	Dr Patrick Gallois
Co-Investigators / Co-Supervisors	Dr Vitalie Rotari
Institution	The University of Manchester
Department	Life Sciences
Funding type	Research
Value (£)	68,172
Status	Completed
Type	Research Grant
Start date	16/06/2003
End date	16/06/2004
Duration	12 months

Abstract

Comparative genomics using numerous complete genomes of prokaryotes and eukaryotes is providing new insights into the common origin of eukaryotic PCD. This leads to the hypothesis that plant metacaspases are the functional homologues of animal caspases, proteases that act as regulator of cell death. We have established that one of the Arabidopsis metacaspase gene (MTC- 8) is induced in the early stage of PCD. We propose i) to analyse the enzymatic activity of 2 metacaspases in vitro using recombinant proteins ii) to carry out a functional study using a knockout mutant of MTC-8 iii) to characterise the mechanism by which MTC-8 expression is induced during PCD in plants, using a mutant screen for altered expression patterns of MTC-8.

Summary

unavailable

Committee	Closed Committee - Plant & Microbial Sciences (PMS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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