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Exploring the Escherichia coli FNR modulon: a post genomic approach

Reference	P19192
Principal Investigator / Supervisor	Professor J Green
Co-Investigators / Co-Supervisors	Professor Robert K Poole
Institution	University of Sheffield
Department	Molecular Biology and Biotechnology
Funding type	Research
Value (£)	215,388
Status	Completed
Type	Research Grant
Start date	01/06/2003
End date	31/10/2006
Duration	41 months

Abstract

The E. coli FNR protein is a global regulator, controlling the expression of more than 50 genes, in response to oxygen availability. Promoters of target genes possess a sequence that closely matches the FNR binding site consensus (TTGATN4ATCAA). The E. coli genome sequence and advances in genomic technologies offer opportunities to gain new insight into the full extent of the FNR modulon and the cellular processes that are influenced by oxygen availability. It is proposed to analyse the genome sequence to identify all the possible functional FNR sites. Transcriptomics will then be used to test these predictions and thereby obtain a global view of the regulatory activities of FNR. New members of the FNR modulon with unusual promoter architectures will then be selected for detailed characterisation of their regulation and function.

Summary

unavailable

Committee	Closed Committee - Plant & Microbial Sciences (PMS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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