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Natural product regulation: control of carbapenem antibiotic biosynthesis in Erwinia carotovora
Reference
P19189
Principal Investigator / Supervisor
Professor George Salmond
Co-Investigators /
Co-Supervisors
Institution
University of Cambridge
Department
Biochemistry
Funding type
Research
Value (£)
231,388
Status
Completed
Type
Research Grant
Start date
01/11/2003
End date
31/10/2006
Duration
36 months
Abstract
This project involves a genetic and physiological analysis of carbapenem antibiotic regulation in Erwinia carotovora (Ecc). Carbapenem is a secondary metabolite and its production in Ecc is under quorum sensing control. In this project we will dissect the regulatory inputs to antibiotic biosynthesis, either channelled through the quorum sensing system or acting independently. We will investigate the regulatory inputs to quorum sensing control of carbapenem synthesis; study the process of glycerol-mediated control of antibiotic production; dissect thermoregulation of the antibiotic; investigate anaerobic repression of quorum sensing and carbapenem; and characterise ribosomal protein-dependent modulation of antibiotic synthesis.
Summary
unavailable
Committee
Closed Committee - Plant & Microbial Sciences (PMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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