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Flavohaemoglobin: a bifunctional NO-Detoxifying enzyme for facultatively aerobic bacteria
Reference
P18939
Principal Investigator / Supervisor
Professor Robert K Poole
Co-Investigators /
Co-Supervisors
Institution
University of Sheffield
Department
Molecular Biology and Biotechnology
Funding type
Research
Value (£)
221,180
Status
Completed
Type
Research Grant
Start date
14/04/2003
End date
13/07/2006
Duration
39 months
Abstract
The flavohaemoglobin Hmp of Escherichia coli and Salmonella provides protection from NO and nitrosative stress (for example in macrophages) by converting NO to nitrate (aerobically) or nitrous oxide (anoxically). The objectives of this work are to: (a) evaluate the role(s) of Hmp in physiologically relevant oxygen-limited and anoxic survival conditions, (b) dissect the roles of the haem and flavin domains of Hmp in ligand binding and catalysis, (c) seek new regulators of hmp transcription, and (d) identify additional mechanisms for NO and nitrosative stress tolerance in the absence of Hmp.
Summary
unavailable
Committee
Closed Committee - Plant & Microbial Sciences (PMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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