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Cell-cell signalling and the control of programmed cell death in Arabidopsis

Reference	P18832
Principal Investigator / Supervisor	Professor Chris Leaver
Co-Investigators / Co-Supervisors	Dr Kerrie McDonald
Institution	University of Oxford
Department	Plant Sciences
Funding type	Research
Value (£)	208,552
Status	Completed
Type	Research Grant
Start date	22/04/2003
End date	21/09/2006
Duration	41 months

Abstract

Cell signals are known to regulate cell survival and cell death, however little is known about the nature of these signals and how they operate in plants. We have established a system in which conditioned medium from Arabidopsis cell cultures can be used to promote cell survival in low density cell cultures that would otherwise undergo Programmed Cell Death (PCD). We propose to: (1) identify and purify the survival factor(s) in the conditioned medium, (2) study the role of sphingolipid metabolites in regulating cell death and survival, and (3) identify and investigate the role of key proteins (and the corresponding genes) involved in cell survival whose expression is modified by addition of purified survival factor(s).

Summary

unavailable

Committee	Closed Committee - Plant & Microbial Sciences (PMS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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