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The molecular mechanism of activation of NBS-LRR proteins

Reference	P18617
Principal Investigator / Supervisor	Professor Sir David Baulcombe
Co-Investigators / Co-Supervisors	Dr Peter Moffett
Institution	University of East Anglia
Department	Sainsbury Laboratory
Funding type	Research
Value (£)	262,928
Status	Completed
Type	Research Grant
Start date	01/01/2003
End date	30/09/2006
Duration	45 months

Abstract

The Rx CC-NBS-LRR protein confers resistance to potato virus X, with the viral coat protein (CP) acting as elicitor. We have previously defined two protein-protein interactions that take place between domains of Rx. These interactions are disrupted upon exposure to CP and appear to be required for Rx activity. We intend to follow up this work in order to characterise the mechanism by which plant CC-NBS-LRR proteins confer resistance. The specific aims are to understand the precise nature of the interactions, their elicitor mediated disruption and how these events act as a molecular switch to transmit information on the presence of elicitor to signalling components. We will also attempt to identify these signalling components.

Summary

unavailable

Committee	Closed Committee - Plant & Microbial Sciences (PMS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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