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The mechanism of action of SFR6 a key regulator of gene expression and cold acclimation

Reference	P18613
Principal Investigator / Supervisor	Professor Hugh Dickinson
Co-Investigators / Co-Supervisors	Professor Marc Knight
Institution	University of Oxford
Department	Plant Sciences
Funding type	Research
Value (£)	195,920
Status	Completed
Type	Research Grant
Start date	01/11/2003
End date	31/10/2006
Duration	36 months

Abstract

The SFR6 protein is essential for cold acclimation in Arabidopsis. The sfr6 mutant is unable to cold acclimate, and shows greatly reduced expression of cold and drought genes. This occurs by virtue of SFR6 action specifically through the DRE promoter and 2 families of transcription factors (TFs), namely DREB1 and DREB2. The nature of this posttranscriptional effect of SFR6 upon the DREB TFs is unknown. This project will determine the mechanism of action of SFR6 upon DREB TFs, by determining effects upon DREB protein levels, production, stability, activity and cellular localisation. This is a combination with a parallel effort to clone the SFR6 gene will determine the role of this key regulator of plant cold acclimation and gene expression.

Summary

unavailable

Committee	Closed Committee - Plant & Microbial Sciences (PMS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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