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Modulators of plant defence responses; functional characterisation of the RPM1 signalling network
Reference
P18600
Principal Investigator / Supervisor
Professor Murray Grant
Co-Investigators /
Co-Supervisors
Institution
Imperial College London
Department
Agricultural Sciences
Funding type
Research
Value (£)
229,220
Status
Completed
Type
Research Grant
Start date
08/09/2003
End date
07/12/2006
Duration
39 months
Abstract
We have identified four proteins interacting with the apoptotic ATPase domain of the plant disease resistance protein RPM1. Ecotopic expression of two interactors, RIN12, and RIN13, abrogates RPM1 mediated hypersensitive cell death and restricts growth of bacteria expressing the type III effector, AvrRpm1. Growth of bacteria carrying avrRpm1 is significantly enhanced in both RIN12 and RIN13 antisense plants. Additionally, RIN12 antisense plants display an accelerated HR. RIN12 and RIN13 function as negative regulators of HR but positive regulators of resistance. We will dissect the function and interaction of these proteins in the RPM1 defence complex using an integrated biochemical, transcriptomics and targeted proteomics approach.
Summary
unavailable
Committee
Closed Committee - Plant & Microbial Sciences (PMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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