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Signal transduction microtubule dynamics and calcium signalling during vegetative hyphal fusion in neurospora

Reference	P18594
Principal Investigator / Supervisor	Professor Nick Read
Co-Investigators / Co-Supervisors	Dr Patrick Hickey
Institution	University of Edinburgh
Department	Inst of Cell and Molecular Biology
Funding type	Research
Value (£)	156,664
Status	Completed
Type	Research Grant
Start date	12/06/2003
End date	11/06/2006
Duration	36 months

Abstract

Mycelial morphogenesis involves the integration of hyphal tip extension, branching and fusion. Little is known about the cell biology of vegetative hyphal fusion. Aims of this study will be to determine whether: (1) Signal transduction during vegetative hyphal fusion in Neurospora is similar to that involved in mating cell fusion in budding yeast (involving mutant analysis by live-cell imaging). (2) The Spitzenkorper act as a microtubule organising centre and regulates the transport of secretory vesicles to sites required for hyphal homing (involving GFP-imaging, immunocytochemical techniques and inhibitor studies). (3) Calcium signalling regulates hyphal homing and fusion (involving calcium imaging and inhibitor studies).

Summary

unavailable

Committee	Closed Committee - Plant & Microbial Sciences (PMS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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