Award details

Pan-genome element sensors

Reference	P18581
Principal Investigator / Supervisor	Professor Nigel Robinson
Co-Investigators / Co-Supervisors	Dr Jennifer Cavet, Professor Bernard Connolly
Institution	Newcastle University
Department	Inst for Cell and Molecular Biosciences
Funding type	Research
Value (£)	215,864
Status	Completed
Type	Research Grant
Start date	01/09/2003
End date	31/10/2006
Duration	38 months

Abstract

Inorganic elements are essential nutrients and potent toxins. Biotic (symbioses, pathogenesis), anthropogenic (pollution, axenic culture, medicines) and abiotic factors alter element concentrations. Bacteria must detect these transients to survive. How do cells discern different elements? Element-discrimination by the SmtB/ArsR- family of transcriptional regulators is understood in more detail than any other type of sensor. Genomes have been searched and six sensors selected that we predict detect new (for this family) elements and/or have atypical sensory sites. For each, we will discover; elements that mediate allostery in vitro via fluorescence anisotropy; inducers in vivo; relative affinities and sensory sites at the sub- molecular level.

Summary

unavailable

Committee	Closed Committee - Plant & Microbial Sciences (PMS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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