Award details

Genetic and biochemical analyses of non-host resistance in Arabidopsis to bacterial pathogens

Reference	P18565
Principal Investigator / Supervisor	Professor Chris Lamb
Co-Investigators / Co-Supervisors	Dr Merritt Crooks
Institution	John Innes Centre
Department	Biological Chemistry
Funding type	Research
Value (£)	242,588
Status	Completed
Type	Research Grant
Start date	01/04/2003
End date	31/03/2006
Duration	36 months

Abstract

Arabidopsis extracts exhibit a selective bactericidal activity that rapidly kills pathovars of Pseudomonas that are non-pathogenic on Arabidopsis but does not affect pathovars for which Arabidopsis is a host. We have used these extracts to screen a P. syringae pv. maculicola genomic library and have isolated novel virulence factors that confer resistance to the bactericide in vitro and is required for symptom development in vivo. We propose to define the molecular structure of the bactericide, characterise the enzymatic activity of the corresponding bacterial virulence factors and identify Arabidopsis mutants affecting the production of this bactericide. This research should provide important insights about the function of these virulence factors in host range determination and the function of this bactericide in non-host resistance as a platform for developing new ways of developing durable resistance in crop plants.

Summary

unavailable

Committee	Closed Committee - Plant & Microbial Sciences (PMS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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