Award details

The trcRS regulon of Mycobacterium tuberculosis

Reference	P18545
Principal Investigator / Supervisor	Professor Neil Stoker
Co-Investigators / Co-Supervisors	Dr Sharon Kendall
Institution	Royal Veterinary College
Department	Pathology and Infectious Diseases-London
Funding type	Research
Value (£)	207,268
Status	Completed
Type	Research Grant
Start date	06/01/2003
End date	05/05/2006
Duration	40 months

Abstract

The trcRS two-component signal transduction system of Mycobacterium tuberculosis is induced in early but not late exponential growth, and also appears to control growth in vivo. We wish to identify the regulon under the control of these genes. Microarray analysis of gene expression in a trcS mutant revealed four highly up-regulated genes, including a bacterioferritin gene bfrB, but there is evidence that these are TrcR-independent; we propose here a series of experiments to identify and analyse the true regulon. In addition we have developed a model for expression of bfrB and co-regulated genes, which we wish to test.

Summary

unavailable

Committee	Closed Committee - Plant & Microbial Sciences (PMS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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