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Oxidative stress resistance in Staphylococcus aureus
Reference
P18537
Principal Investigator / Supervisor
Professor Simon J. Foster
Co-Investigators /
Co-Supervisors
Institution
University of Sheffield
Department
Molecular Biology and Biotechnology
Funding type
Research
Value (£)
199,448
Status
Completed
Type
Research Grant
Start date
01/05/2003
End date
01/05/2006
Duration
36 months
Abstract
Oxidative stress resistance is important for all aerobic organisms and is exacerbated by the need most bacteria have for the redox active metal iron. In Staphylococcus aureus, iron and manganese (Mn(II)) homeostasis and peroxide resistance are co-regulated. Uptake of Mn(II) is required for full resistance to superoxide (Mn(II)) had been hypothesised to remove superoxide directly via redox reactions, which may form an efficient mechanism of stress resistance that is common amongst bacteria. The proposed project will establish the mechanism and contribution of the Mn(II) associated superoxide scavenging to stress resistance. Also the project will determine the functional interrelationships between oxidative stress resistance components.
Summary
unavailable
Committee
Closed Committee - Plant & Microbial Sciences (PMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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