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The role and mode of action of Sph1/74 a novel class of protein signal molecule from Arabidopis thaliana

Reference	P18254
Principal Investigator / Supervisor	Professor Chris Franklin
Co-Investigators / Co-Supervisors	Professor Vernonica E. (Noni) Franklin-Tong, Dr Jonathan Paul Ride, Dr Mike Wheeler
Institution	University of Birmingham
Department	Sch of Biosciences
Funding type	Research
Value (£)	226,836
Status	Completed
Type	Research Grant
Start date	01/12/2002
End date	01/12/2005
Duration	36 months

Abstract

Many developmental and cellular processes in animals are regulated by cellular communication mediated by protein ligands. By contrast few corresponding examples have been identified in plants. Arabidopsis genome sequencing has revealed at least three extensive gene families that may encode such molecules. Recently we have obtained evidence that a member of one of these families of orphan ligands, SPH1/74, encodes a biologically active product that is essential for normal development. We aim to dissect the function of Sph1/74 and establish how this is integrated into the growth and developmental pathways of the plant. Expression of the gene and protein will be investigated using in situ- hybridisation, immunolocalisation and GFP fusions. Microarray analysis will be used to establish the gene-networks associated with Sph1/74 signalling. Phage-display will be used to identify putative Sph1/74 interacting partners.

Summary

unavailable

Committee	Closed Committee - Plant & Microbial Sciences (PMS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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