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Developing a functional flagellar toolkit by studying chimeric proteins
Reference
P18196
Principal Investigator / Supervisor
Professor Renee Sockett
Co-Investigators /
Co-Supervisors
Institution
University of Nottingham
Department
School of Molecular Medical Sciences
Funding type
Research
Value (£)
188,204
Status
Completed
Type
Research Grant
Start date
01/10/2003
End date
30/09/2006
Duration
36 months
Abstract
Our previous work has revealed that limited interchange of certain subdomains of diverse MOT and FliG proteins gives insights into the mechanisms of bacterial flagellar rotation. This proposal builds on those previous data and aims to further relate motor and rotor protein domains to flagellar activities, by creating and testing the properties of chimeric proteins constructed pairwise from bacterial flagella with different rotational characteristics or with different driving ions for motility. We will also exploit a recently constructed motile, tactic, R. sphaeroides EGFP-FliM fusion to purify and analyse the protein content of the C ring switch from this flagellar motor.
Summary
unavailable
Committee
Closed Committee - Plant & Microbial Sciences (PMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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