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Life beyond fur - novel regulators and novel targets in the iron regulon of Rhizobium
Reference
P18067
Principal Investigator / Supervisor
Professor Andrew Johnston
Co-Investigators /
Co-Supervisors
Institution
University of East Anglia
Department
Biological Sciences
Funding type
Research
Value (£)
179,232
Status
Completed
Type
Research Grant
Start date
01/08/2003
End date
31/07/2006
Duration
36 months
Abstract
We showed that Rhizobium has many systems of Fe transport, several resembling those found hitherto in pathogens. Transcription of uptake genes occurs only in low-Fe conditions, but the control system(s) differ markedly from E. coli. The Fur regulator is not involved, but two genes, girA and uirA, regulate at least 8 Fe-responsive promoters. Using proteomics and genetics, we will compile an audit of Fe-repressed genes. We will analyse the role of GirA and UirA in the Fe-regulon(s) exploiting the Rhizobium genomic sequence soon to be available. In collaborations, we will analyse corresponding regulators in Brucella and Paracoccus to demonstrate the ubiquity of these new control systems.
Summary
unavailable
Committee
Closed Committee - Plant & Microbial Sciences (PMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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