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Functional analysis of fungal phosphopantetheinyl transferase
Reference
P18058
Principal Investigator / Supervisor
Professor Geoffrey Turner
Co-Investigators /
Co-Supervisors
Institution
University of Sheffield
Department
Molecular Biology and Biotechnology
Funding type
Research
Value (£)
215,808
Status
Completed
Type
Research Grant
Start date
15/02/2003
End date
15/02/2006
Duration
36 months
Abstract
A wide range of enzyme apoproteins involved in secondary and primary metabolism require addition of a 4-phosphopantetheine cofactor in order to function. This modification is carried out by phosphopantetheinyl transferases, which are widely distributed in prokaryotes and eukaryotes, and differ in specificity. The first candidate gene in antibiotic-producing filamentous fungi, Aspergillus nidulans and A. fumigatus, has recently been identified, and appears to encode a broad specificity enzyme. A combination of genetic and biochemical approaches will be used to investigate its biological role, and to develop tools for heterologous expression of active multienzyme complexes responsible for antibiotic and toxin synthesis.
Summary
unavailable
Committee
Closed Committee - Plant & Microbial Sciences (PMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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