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The biological significance of the targeting function of carbohydrate binding modules

Reference	P17959
Principal Investigator / Supervisor	Professor Harry Gilbert
Co-Investigators / Co-Supervisors	Professor Paul Knox
Institution	Newcastle University
Department	Agriculture Food and Rural Development
Funding type	Research
Value (£)	236,352
Status	Completed
Type	Research Grant
Start date	01/03/2003
End date	28/02/2006
Duration	36 months

Abstract

Prokaryotic plant cell wall hydrolases comprise catalytic domains and non-catalytic carbohydrate binding modules (CBMs). These enzymes contain a repertoire of CBMs that exhibit very different specificities for plant structural polysaccharides. Currently the evolutionary rationale for the diversity of bacterial CBMs is unclear. In this research programme we will investigate the biological significance of the extensive range of CBMs present in the prokaryotic hydrolytic enzymes by testing the hypotheses that: i) CBMs play a pivotal role in the targeting of degradative enzymes to specific locations within cell walls, and ii) the targeting function of these modules increase the efficiency of the hydrolytic process by increasing the extent of cell wall degradation, and mediating synergistic interactions between enzymes, with different substrate specificities that are targeted to the same region of the cell wall.

Summary

unavailable

Committee	Closed Committee - Plant & Microbial Sciences (PMS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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