Award details

The fungal pH response system and its role in virulence

Reference	P17835
Principal Investigator / Supervisor	Emeritus Professor Herbert Arst
Co-Investigators / Co-Supervisors	Professor David Bignell, Professor Ken Haynes
Institution	Imperial College London
Department	Dept of Medicine
Funding type	Research
Value (£)	353,808
Status	Completed
Type	Research Grant
Start date	01/04/2003
End date	30/09/2006
Duration	42 months

Abstract

Fluctuation in ambient pH leads to changes in fungal gene expression that can influence fungal virulence. Using a combination of fungal genetics, molecular biology and clinical mycology, we will identify common and species-specific components of the fungal pH response system (FPRS). This will initially involve global transcriptomic and proteomic screens of Saccharomyces cerevisiae and Candida albicans at different pHs and then these data will be used to study the FPRS in the fungal pathogen Aspergillus fumigatus. A comprehensive collection of S. cerevisiae null mutants will be screened to identify novel regulators of the FPRS. The role of components of the FPRS in the virulence of the pathogens C. albicans and A. fumigatus will be assessed using murine models of disease. This project will provide new information on the FPRS and its regulation, the role it plays in fungal virulence and will identify new potential antifungal targets. (Joint with grant 17836).

Summary

unavailable

Committee	Closed Committee - Plant & Microbial Sciences (PMS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

Associated awards:

P17836 The fungal pH response system and its role in virulence

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