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Functional analysis of FHY1: a key regulator of phytochrome A signalling

Reference	P17802
Principal Investigator / Supervisor	Professor Simon Moller
Co-Investigators / Co-Supervisors	Dr DJ Nichols
Institution	University of Leicester
Department	Biology
Funding type	Research
Value (£)	179,060
Status	Completed
Type	Research Grant
Start date	02/06/2003
End date	02/06/2006
Duration	36 months

Abstract

How light signals are transduced at the subcellular level from phytochrome via signalling proteins leading to altered gene expression profiles remains unknown. Recent evidence suggests that early phytochrome A signalling events are nuclear and that nucleo-cytoplasmic partitioning of both phytochrome and signalling intermediates provide an elegant control mechanism for phyA signal transduction. We have cloned FHY1, a key nuclear regulator of phyA signalling that shows light-dependent nuclear translocation patterns. Using a cell biological approach we will dissect FHY1 nucleo-cytoplasmic partitioning dynamics and together with the identification of FHY1 interacting proteins we will elucidate FHY1 mode of action. The cloning of an FHY1 homolog and fhy1 suppressor mutants will allow us to integrate the action of FHY1 into the overall subcellular phyA signalling network.

Summary

unavailable

Committee	Closed Committee - Plant & Microbial Sciences (PMS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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