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Functional genomics of pathogenicity in the Pseudomonas syringae/Arabidopsis interaction

Reference	P17289
Principal Investigator / Supervisor	Professor John Mansfield
Co-Investigators / Co-Supervisors	Professor Murray Grant
Institution	Imperial College London
Department	Biological Sciences
Funding type	Research
Value (£)	323,776
Status	Completed
Type	Research Grant
Start date	01/10/2002
End date	01/10/2005
Duration	36 months

Abstract

The aim is to develop a comprehensive understanding of the function of the effector proteins used by P.s. pv.tomato strain DC3000 to establish a parasitic relationship with its host Arabidopsis. We will utilize the genomic sequences now available for both the pathogen and host to identify bacterial effectors and their targets in the plant. The programme involves 1) cloning effector genes based on function and promoter motif, and their categorisation in terms of the macroscopic symptoms they generate; 2) identification of their molecular phenotypes via analysis of plant gene expression in stably transformed Arabidopsis using microarrays, 3) identification of interacting plant proteins by yeast 2-hybrid technology.

Summary

unavailable

Committee	Closed Committee - Plant & Microbial Sciences (PMS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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