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Functional analysis of acetyl CoA/alpha-keto acid condensation genes in Arabidopsis and their role in primary and secondary metabolism

Reference	P17158
Principal Investigator / Supervisor	Professor Richard Mithen
Co-Investigators / Co-Supervisors	Professor Jeremy Roberts
Institution	University of Nottingham
Department	Sch of Biosciences
Funding type	Research
Value (£)	195,660
Status	Completed
Type	Research Grant
Start date	22/07/2002
End date	21/11/2005
Duration	40 months

Abstract

We propose the functional analyses of two members of a four-member gene family in Arabidopsis, which catalyse the condensation of acetyl CoA with alpha-keto acids. These reactions occur in two pathways; firstly as part of leucine synthesis in primary metabolism, and secondly in the synthesis of methionine-derived chain-elongated glucosinolates in secondary metabolism. We have shown that two members of this family function in the synthesis of medium and long chain glucosinolates. We wish to test two hypothesis: Firstly, that of the remaining two members, one functions in leucine biosynthesis, and one functions in the synthesis of short chain glucosinolates. Secondly, that modifying the expression of the glucosinolate gene will have a major effect on the levels of all chain elongated glucosinolates, thereby testing a model of glucosinolate biosynthesis.

Summary

unavailable

Committee	Closed Committee - Plant & Microbial Sciences (PMS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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