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A whole genome analysis of two-component system signal transduction pathways in Myxococcus xanthus
Reference
P16665
Principal Investigator / Supervisor
Professor David Hodgson
Co-Investigators /
Co-Supervisors
Professor D E Whitworth
Institution
University of Warwick
Department
Biological Sciences
Funding type
Research
Value (£)
217,256
Status
Completed
Type
Research Grant
Start date
22/03/2002
End date
21/09/2005
Duration
42 months
Abstract
Two component systems regulate diverse cellular functions. We propose a whole-genome analysis of interactions between two-component system proteins in Myxococcus xanthus, an ideal model organism, which has a multitude of such proteins including novel hybrid forms. A yeast two-hybrid system will allow direct detection of protein-protein interactions. Information obtained will allow determination of cross-talk and/or redundancy between pathways and pairing of histidine kinases to response regulators, areas refractory to traditional genetic approaches. Results will be confirmed by strategic gene disruptions and mutagenesis. The yeast two-hybrid system will be used further to find unidentified proteins interacting with input or output domains.
Summary
unavailable
Committee
Closed Committee - Plant & Microbial Sciences (PMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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