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Dissection of defence-related signalling via gain-of-function genetics
Reference
P16595
Principal Investigator / Supervisor
Professor Gary Loake
Co-Investigators /
Co-Supervisors
Institution
University of Edinburgh
Department
Inst of Cell and Molecular Biology
Funding type
Research
Value (£)
281,500
Status
Completed
Type
Research Grant
Start date
01/01/2002
End date
28/02/2006
Duration
50 months
Abstract
Systematic gain-of-function genetics has proved a highly successful strategy for ascribing gene function in model eukaryotes. We have developed a targeted gain-of-function screen and deployed it to uncover a number of novel defence-related mutants. We will complete the detailed characterisation of these mutants which will include: comprehensive epistasis analysis; gene expression microarrays; and, directed metabolite profiling. Furthermore, we will also isolate and characterise the corresponding mutated genes. Finally, we will utilise a large collection of unique T-DNA tagged lines to undertake two complementary forward screens to uncover additional gain-of-function mutants and their corresponding genes.
Summary
unavailable
Committee
Closed Committee - Plant & Microbial Sciences (PMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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