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The function of histidine kinases during oxidative stress responses in Arabidopsis

Reference	P16453
Principal Investigator / Supervisor	Professor Steven Neill
Co-Investigators / Co-Supervisors	Dr Radhika Desikan, Dr John Travers Hancock, Dr Richard Hooley
Institution	University of the West of England
Department	Faculty of Health and Applied Sciences
Funding type	Research
Value (£)	201,764
Status	Completed
Type	Research Grant
Start date	01/06/2002
End date	01/06/2005
Duration	36 months

Abstract

Hybrid histidine kinases (HK), which form part of the two-component system, have been shown to be hydrogen peroxide sensing proteins in yeast. Several HKs exist in Arabidopsis, some of which function as sensors for ethylene, cytokinin and osmotic stress. We have identified a HK whose expression is up-regulated by hydrogen peroxide. This project will investigate the function of HKs in oxidative stress responses via two approaches. The first will use hydrogen peroxide-sensitive Arabidopsis HK genes to functionally complement yeast mutants in that are deficient in the hydrogen peroxide-sensitive HK. The second will utilise a parallel reverse genetics approach, in which Arabidopsis insertion mutant libraries will be screened for HK mutants, and their hydrogen peroxide sensitivity investigated.

Summary

unavailable

Committee	Closed Committee - Plant & Microbial Sciences (PMS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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