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Investigation of the role of cyclophilins in plant growth and development

Reference	P16446
Principal Investigator / Supervisor	Professor Peter Horton
Co-Investigators / Co-Supervisors	Professor Julie Gray
Institution	University of Sheffield
Department	Molecular Biology and Biotechnology
Funding type	Research
Value (£)	181,868
Status	Completed
Type	Research Grant
Start date	12/02/2002
End date	11/10/2005
Duration	44 months

Abstract

Cyclophilins are a class of highly conserved ubiquitous proteins that are suggested to play key roles in various central cell processes such as intracellular signalling and protein assembly. In Arabidopsis they are encoded by a family (ROC) of 23 genes, but their function is poorly understood. We have discovered a putative chloroplast cyclophilin encoded by the ROC8 gene and in this project, its cellular location, expression pattern during development, role in plant responses to the environment and cellular protein targets will be determined. Exploiting the availability of mutants containing knockouts in 14 of the ROC genes, the function of selected examples of other plant cyclophilins in plant growth and development will be examined.

Summary

unavailable

Committee	Closed Committee - Plant & Microbial Sciences (PMS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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