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New insights into bacterial outer membrane biosynthesis
Reference
P16414
Principal Investigator / Supervisor
Professor Tracy Palmer
Co-Investigators /
Co-Supervisors
Institution
University of East Anglia
Department
Biological Sciences
Funding type
Research
Value (£)
178,640
Status
Completed
Type
Research Grant
Start date
01/07/2002
End date
01/07/2005
Duration
36 months
Abstract
Strains of Escherichia coli deleted for the Tat protein export pathway show pleiotropic defects in their outer membrane. This phenotype is not due to the mislocalisation of any previously identified Tat substrate protein. This proposal has the following specific objectives: (i) to identify the specific outer membrane defect in the tat mutant strains; (ii) to assess whether the Tat system plays a direct role in outer membrane biogenesis by exporting a critical protein involved in the biogenesis process (iii) to characterise the physiological function of the novel and highly conserved YjeE protein; and (iv) to map further mutations that genetically suppress the outer membrane defect of tat mutants.
Summary
unavailable
Committee
Closed Committee - Plant & Microbial Sciences (PMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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