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Control of expression of chemosensory operons of Rhodobacter sphaeroides and relationship to other regulatory systems

ReferenceP16034
Principal Investigator / Supervisor Professor Judith Armitage
Co-Investigators /
Co-Supervisors
Institution University of Oxford
DepartmentBiochemistry
Funding typeResearch
Value (£) 216,260
StatusCompleted
TypeResearch Grant
Start date 01/09/2001
End date 31/03/2006
Duration55 months

Abstract

Expression of several major metabolic pathways of Rhodobacter sphaeroides is controlled by the Reg system, involving an electron transport dependent phosphorelay. The major chemosensory operon, encoding the critical cytoplasmic receptor, TlpC, is also controlled by this pathway, as is aerotaxis. TlpC is not only essential for all tactic responses, it forms a tight cluster in the cytoplasm which segregates at cell division. We will identify (a) the mechanisms involved in transcriptional regulation and their relationship to other Reg controlled operons; (b) examine the effects of differential expression of the Che proteins on behaviour under different conditions; and (c) identify how Reg proteins control aerotaxis.

Summary

unavailable
Committee Closed Committee - Plant & Microbial Sciences (PMS)
Research TopicsX – not assigned to a current Research Topic
Research PriorityX – Research Priority information not available
Research Initiative X - not in an Initiative
Funding SchemeX – not Funded via a specific Funding Scheme
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