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Responses of Escherichia coli to nitrosative and oxidative stresses in vitro and in macrophage: a post-genomic approach
Reference
P15901
Principal Investigator / Supervisor
Professor Robert K Poole
Co-Investigators /
Co-Supervisors
Professor J Green
,
Professor Robert Read
Institution
University of Sheffield
Department
Molecular Biology and Biotechnology
Funding type
Research
Value (£)
300,280
Status
Completed
Type
Research Grant
Start date
01/07/2002
End date
30/06/2005
Duration
36 months
Abstract
Bacteria are exposed to toxic oxygen-derived species, NO and its congeners in a variety of environments, including with phagolysosomes. This study aims to: (a) exploit post-genomic approaches (gene arrays, proteomics) to understand the breadth of genetic responses mounted by Escherichia coli to nitrosative and oxidative stresses and combinations of these in vitro; (b) mutate genes selected from these studies to describe mutant phenotypes in vitro and the requirements for these genes in resisting macrophage killing, and (c) probe mechanisms of gene regulation.
Summary
unavailable
Committee
Closed Committee - Plant & Microbial Sciences (PMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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