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Novel redox state-dependent regulation of periplasmic nitrate reductase and carbon source selection in P. pantotrophus

Reference	P15877
Principal Investigator / Supervisor	Professor Stuart John Ferguson
Co-Investigators / Co-Supervisors	Professor David Richardson
Institution	University of Oxford
Department	Biochemistry
Funding type	Research
Value (£)	166,348
Status	Completed
Type	Research Grant
Start date	04/03/2002
End date	03/10/2005
Duration	43 months

Abstract

The molecular basis for the repression of anaerobic expression and enhanced aerobic expression of the periplasmic nitrate reductase system of Paracoccus pantotrophus following growth on a relatively reduced carbon source such as butyrate will be elucidated. The outcome is expected to establish the characteristics of a new regulatory system. The extent to which this system relates to the selective utilisation of succinate rather than butyrate as a carbon source for aerobic growth will also be explored. This work will provide a general insight into the use by bacteria of carbon sources, e.g. tricarboxylic acids, that are less reduced rather than those, e.g. butyrate, which are over-reduced relative to the average cell biomass.

Summary

unavailable

Committee	Closed Committee - Plant & Microbial Sciences (PMS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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