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The meiotic kinesin TETRASPORE(TES) its germline specificity and role in plant male meiotic cytokinesis
Reference
P15788
Principal Investigator / Supervisor
Professor Hugh Dickinson
Co-Investigators /
Co-Supervisors
Professor Roderick Scott
Institution
University of Oxford
Department
Plant Sciences
Funding type
Research
Value (£)
227,036
Status
Completed
Type
Research Grant
Start date
21/01/2002
End date
20/02/2005
Duration
37 months
Abstract
TES, constitutively expressed in Arabidopsis, encodes an N-terminal motor kinesin and is essential for simultaneous male meiotic cytokinesis. Male specificity and potential redundancy will be studied through expression of TES homologues, null mutants, and double mutants with cytokinesis-defective lines. The role the N (motor)- and C-termini in establishing cellular domains and cytokinesis will be explored by (i) fusion constructs and antibodies to localise the TES protein through meiosis, (ii) 2-hybrid screens to identify and clone the targets of TES, and studying the stage specificity of their expression, (iii) in vitro motor-function assays. The role of TES in sequential male meiosis will be studied using the maize homologue.
Summary
unavailable
Committee
Closed Committee - Plant & Microbial Sciences (PMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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