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Metal recognition and transcriptional activation by the CueR regulator
Reference
P15753
Principal Investigator / Supervisor
Dr Jonathan Hobman
Co-Investigators /
Co-Supervisors
Institution
University of Birmingham
Department
Sch of Biosciences
Funding type
Research
Value (£)
204,824
Status
Completed
Type
Research Grant
Start date
01/04/2002
End date
01/04/2005
Duration
36 months
Abstract
The CueR regulator of Escherichia coli is a member of the MerR family of transcriptional regulators; it responds to copper and silver salts and controls expression of the major copper export gene (copA) among other genes. The recently-solved structure of one conformation of one member of the MerR family; BmrR, a dye-responsive regulator from Bacillus, has given some further insight into how this family of regulators may cause transcriptional activation. We propose to make mutants of CueR to elucidate the mechanisms of discriminatory recognition of copper and other metals, and to determine the mechanism of gene regulation by this new and experimentally tractable regulator. This will test the current models for the mechanisms of metal-responsive transcriptional activation by MerR family regulators.
Summary
unavailable
Committee
Closed Committee - Plant & Microbial Sciences (PMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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