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Role of FtsH and prohibitin in the repair of photosystem two and the prevention of photoinhibition
Reference
P15724
Principal Investigator / Supervisor
Professor Peter Nixon
Co-Investigators /
Co-Supervisors
Institution
Imperial College London
Department
Biological Sciences
Funding type
Research
Value (£)
212,252
Status
Completed
Type
Research Grant
Start date
17/06/2002
End date
17/06/2005
Duration
36 months
Abstract
An important cause of photoinhibition in plants and cyanobacteria is the light-induced irreversible damage to the D1 subunit of the photosystem two (PSII) complex. This work aims to use the cyanobacterium Synechocystis sp. PCC 6803 to clarify the role of the FtsH and prohibitin proteins in the D1 repair cycle and the maintenance of PSII homeostasis. Recent data indicate a key role for FtsH (slr0228) in this process in vivo. Experiments using whole cells and isolated PSII complexes will aim to (i) test the role of each of the four FtsH homologues in D1 turnover; (ii) purify and analyse a newly discovered PSII complex containing FtsH; (iii) test for the presence of a large prohibitin hetero-oligomer and its involvement in stabilising newly synthesised D1; and (iv) test whether FtsH and prohibitin form a supercomplex within the membrane.
Summary
unavailable
Committee
Closed Committee - Plant & Microbial Sciences (PMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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