Award details

The Rpf bacterial cytokine receptor

Reference	P15718
Principal Investigator / Supervisor	Professor Michael Young
Co-Investigators / Co-Supervisors	Professor Douglas Kell
Institution	Aberystwyth University
Department	Inst of Biological, Environ & Rural Sci
Funding type	Research
Value (£)	219,804
Status	Completed
Type	Research Grant
Start date	01/12/2001
End date	31/05/2005
Duration	42 months

Abstract

The high G+C cohort of Gram-positive bacteria includes important pathogens, such as the mycobacteria, and organisms of biotechnological importance such as the streptomycetes. Their proliferation in nutrient-poor environments is dependent on the production of a family of autocrine growth factors (or cytokines), but whose mode of action remains to be elucidated. This project will use three approaches (bacterial expression libraries, surface display, yeast two-hybrid) to isolate and characterise the surface receptor(s) with which these bacterial cytokines interact. We shall isolate the genes for the receptor(s), produce them in recombinant form and assess the affinity and kinetics of binding of Rpf homologues. Similar strategies will then be used to determine other molecules that form part of the receptor.

Summary

unavailable

Committee	Closed Committee - Plant & Microbial Sciences (PMS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

I accept the terms and conditions of use (opens in new window)

export PDF file

back to list new search