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Characterisation of the RPW8-mediated disease resistance pathway in Arabidopsis

Reference	P15697
Principal Investigator / Supervisor	Professor John Turner
Co-Investigators / Co-Supervisors	Dr Mark John Coleman, Dr Shunyuan Xiao
Institution	University of East Anglia
Department	Biological Sciences
Funding type	Research
Value (£)	321,476
Status	Completed
Type	Research Grant
Start date	01/08/2001
End date	01/08/2004
Duration	36 months

Abstract

A new class of disease resistance gene, named RPW8, which confers resistance in Arabidopsis to a broad spectrum of powdery mildew diseases has recently been reported. Transcription of RPW8 is induced by infection, and unexpectedly, by abiotic stress and wounding also. These treatments induce extensive necrosis in plants containing several copies of the RPW8 transgene. RPW8 binds to an Arabidopsis homologue of a mammalian inhibitor of apoptosis, and down-regulation of this gene in Arabidopsis enhances resistance to powdery mildew disease. Evidently, RPW8 integrates signals from pathogens and from abiotic stress to regulate a cell- death pathway. This project will characterise other components of this signal pathway using genetic, transcriptome and protein-binding assays.

Summary

unavailable

Committee	Closed Committee - Plant & Microbial Sciences (PMS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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