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Molecular analysis of the pathway of bacterial thiosulphate and sulphide oxidation
Reference
P15195
Principal Investigator / Supervisor
Professor Benjamin Berks
Co-Investigators /
Co-Supervisors
Institution
University of Oxford
Department
Biochemistry
Funding type
Research
Value (£)
216,012
Status
Completed
Type
Research Grant
Start date
30/09/2002
End date
29/01/2006
Duration
40 months
Abstract
The Sox system is used by both photosynthetic and non-photosynthetic bacteria to oxidize thiosulphate and sulphide to sulphate. Building upon our BBSRC-funded studies with the model organism Rhodovulum sulfidophilum we aim to elucidate the reactions of the Sox pathway using a combination of biochemical and genetic techniques. The transformations of protein-bound sulphur species will be tracked using mass spectrometry and radiolabelling approaches. The connections between the mechanisms of thiosulphate and sulphide oxidation will be probed including a genetic analysis of the proposal that flavocytochrome c is a sulphide dehydrogenase. The role of a disulphide bond reducing system in the Sox pathway will be investigated.
Summary
unavailable
Committee
Closed Committee - Plant & Microbial Sciences (PMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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