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The programme underlying dormancy and autocrine resuscitation in Mycobacterium bovis BCG

Reference	P15165
Principal Investigator / Supervisor	Professor Michael Young
Co-Investigators / Co-Supervisors	Professor Douglas Kell
Institution	Aberystwyth University
Department	Inst of Biological, Environ & Rural Sci
Funding type	Research
Value (£)	289,436
Status	Completed
Type	Research Grant
Start date	01/05/2001
End date	30/06/2004
Duration	38 months

Abstract

TB is a major public health problem with an estimated one in three of the world population harbouring a latent (persistent) infection. Little is known about control and maintenance of this (dormant?) state. We shall use Rpf, our recently discovered bacterial cytokine, and a newly developed M. bovis BCG dormancy model, together with microarray and proteomic approaches to study the changes in gene expression as bacteria enter into and exit from dormancy. We shall also use flow cytometry to correlate the biochemical activities in individual cells with (a) the loss (and gain) of culturability and (b) the changes in gene expression, and thereby distinguish between programmed vs. stochastic mechanisms for entry into and exit from the dormant state.

Summary

unavailable

Committee	Closed Committee - Plant & Microbial Sciences (PMS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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